Objective: Genitourinary tract infections play a significant role in male infertility. Infections of reproductive sex glands, such as the prostate, impair function and indirectly affect male fertility. The general aim of this study is to investigate the protective effect of Korean red ginseng (KRG) on Prostatitis in male rats treated with ciprofloxacin (CIPX).Materials and Methods: In this experimental study, we randomly divided 72 two male Wistar rats into 9 groups. The groups were treated as follows for 10 days: i. Control (no medication), ii. Sham [(normal saline injection into the vas deferens and oral administration of phosphate-buffered saline (PBS)], iii. Ginseng, iv. CPIX, v. CIPX+ginseng, vi. Uropathogenic Escherichia coli (E. coli) (UPEC), vii. UPEC+ginseng, viii. UPEC+CIPX, and ix. UPEC+ginseng+CIPX. The rats were killed 14 days after the last injection and the prostate glands were removed. After sample preparation, routine histology was performed using hematoxylin and eosin staining. The terminal deoxynucleotidyl transferase mediated dUTP-biotin nick end labeling (TUNEL) method was used to determine the presence of apoptotic cells.Results: The severity score for acinar changes and inflammatory cell infiltration in the UPEC+CIPX group did not significantly different from the UPEC group. However this score significantly decreased in the UPEC+CIPX+ginseng group compared to the UPEC group. Apoptotic index of all ginseng treated groups significantly decreased compared to the UPEC and CPIX groups.Conclusion: These results suggested that ginseng might be an effective adjunct in CIPX treatment of Prostatitis. The combined use ginseng and CIPX was more effective than ginseng or CIPX alone.

Introduction The purpose of the current study was to investigate the separation of the Bacterial factors of men’ s urinary tract infections using the prostate massage technique and comparing them with the initial-stream urine, midstream urine, and end-stream urine in Tehran’ s Health Centers. Methods In this study, samples were collected from 50 men with genital-urinary tract defects who were referred to medical centers. During sampling, demographic information, medical history, and drugs are taken were asked from patients. Prostate secretions and first-void urine (VB1) were collected from the first 25 patients, while prostate secretions and VB1, midstream urine (VB2), and end-stream urine (VB3) were collected from the second 25 patients. Results Using prostate secretions culture, out of the first 25 samples, 7 samples (28%) were infected by Mycoplasma hominis and 9 samples (36%) were infected by Ureaplasma urealyticum. using VB1 culture it was analyzed that 6 samples (24%) were infected by Mycoplasma hominis and 8 samples (32%) were infected by Ureaplasma urealyticum. In the second 25 samples, Bacterial contamination was seen in 23 samples (92%) by prostate secretions culture. VB1 culture showed Bacterial contamination in 14 samples (56%). VB2 and VB3 cultures showed Bacterial contamination in 3 (12%) and only 2 samples (8%), respectively. Conclusions In conclusion, the results obtained from the prostate secretions culture were more accurate and precise than the VB1 culture, but they were close to each other. Therefore, instead of using prostate massage which can be irritating for the patients or if the patient does not have prostate secretions, VB1 culture can be used.

Background and Objective: Non-specific granulomatous Prostatitis is an uncommon diffuse inflammatory condition of the prostate. It is important because it may be mistaken for prostatic carcinoma. The aim of the study was to determine the prevalence of non-specific granulomatous Prostatitis (NSGP) and comparing the results of transrectal ultrasonography, serum prostate specific antigen (PSA) and free prostate specific antigen levels, digital rectal exam (DRE) in NSGP with the prostate carcinoma and benign prostate hyperplasia.Materials and Methods: During a cross-sectional study, the prostate needle biopsy cases with the granulomatosts Prostatitis diagnosis that had been referred to one of the largest pathology centers (1 year: 2006) were found and their clinical files were revised from the point of DRE, transrectal ultrasonography (TRUS), fPSA, and PSA. Some clinical and pathology findings such as age, microscopic findings, sonography information and experimental findings that had been necessary for the study were gathered and analyzed using SPSS software.Results: Out of 783 needle biopsies of prostate, 8 (1.02%) cases were non-specific granulomatous Prostatitis. The age range of patients was 55-76 years (with a mean of 66.1 years). Mean of PSA level was 19.45 ng/ml and fPSA level was 0.7 ng/ml. In 2 patients, TRUS showed focal hypoechoic areas and in other 2 of these DRE revealed asymmetry and mild nodularity.Conclusion: There is no pattern of clinical, biochemical or ultrasound findings that allows a specific diagnosis of granulomatous Prostatitis to be made or differentiate it from prostatic carcinoma and the biopsy is still necessary for the certain disease diagnosis.